[HTML][HTML] Association between IL-37 and VEGF Gene Expression in Psoriasis Pathogenesis in Egyptian Population
SM El-Sherbini, AKS Salama, LA Rashed… - Journal of Biosciences …, 2022 - scirp.org
Journal of Biosciences and Medicines, 2022•scirp.org
Background: Psoriasis is considered a common skin disease, marked by the production and
elevation of inflammatory plaques that regularly shed scales resulting from extensive skin
epithelial cell proliferation. T lymphocytes, neutrophils, and other leukocytes enter the
irritated skin, resulting in epidermal keratinocyte hyperplasia, vascular hyperplasia, ectasia,
and T lymphocyte, neutrophil other forms of leukocyte infiltration. Aim of the Work: the study
aimed to investigate the role of IL-37 and VEGF gene expression in the pathogenesis of …
elevation of inflammatory plaques that regularly shed scales resulting from extensive skin
epithelial cell proliferation. T lymphocytes, neutrophils, and other leukocytes enter the
irritated skin, resulting in epidermal keratinocyte hyperplasia, vascular hyperplasia, ectasia,
and T lymphocyte, neutrophil other forms of leukocyte infiltration. Aim of the Work: the study
aimed to investigate the role of IL-37 and VEGF gene expression in the pathogenesis of …
Background
Psoriasis is considered a common skin disease, marked by the production and elevation of inflammatory plaques that regularly shed scales resulting from extensive skin epithelial cell proliferation. T lymphocytes, neutrophils, and other leukocytes enter the irritated skin, resulting in epidermal keratinocyte hyperplasia, vascular hyperplasia, ectasia, and T lymphocyte, neutrophil other forms of leukocyte infiltration.
Aim of the Work
the study aimed to investigate the role of IL-37 and VEGF gene expression in the pathogenesis of psoriasis in Egyptian patients.
Methodology
Polymerase chain reaction techniques (PCR) were applied to detect VEGF in the skin homogenates of psoriasis patients. In addition, the ELIZA technique was applied to investigate IL-37 in skin homogenates. One hundred cases have been divided into two groups: 50 healthy volunteers as the group I healthy control; 50 psoriasis patients as group II. PCR real-time technology was assessed through extracted DNA samples for VEGF amplification in skin homogenate.
Result
Our results revealed that psoriasis patients significantly had a substantial reduction in IL-37 compared to the control group (p < 0.001). However, there was a significant increase (p < 0.001) in VEGF in psoriasis patients compared to the control group.
Conclusion
There is a significant inverse association between IL-37 and VEGF in psoriasis patients. Study findings revealed that IL-37 gene expression decreases while VEGF gene expression increases in psoriatic individuals. Such a measurement may be beneficial in determining the severity of the condition, as well as taking into consideration of the disease’s diagnosis.
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