Association between the PARP1 Val762Ala Polymorphism and Cancer Risk: Evidence from 43 Studies
Background Poly (ADP-ribose) polymerase-1 (PARP-1) plays critical roles in the detection
and repair of damaged DNA, as well as cell proliferation and death. Numerous studies have
examined the associations between PARP1 Val762Ala (rs1136410 T> C) polymorphism
and cancer susceptibility; nevertheless, the findings from different research groups remain
controversial. Methods We searched literatures from MEDLINE, EMBASE and CBM
pertaining to such associations, and then calculated pooled odds ratio (OR) and 95 …
and repair of damaged DNA, as well as cell proliferation and death. Numerous studies have
examined the associations between PARP1 Val762Ala (rs1136410 T> C) polymorphism
and cancer susceptibility; nevertheless, the findings from different research groups remain
controversial. Methods We searched literatures from MEDLINE, EMBASE and CBM
pertaining to such associations, and then calculated pooled odds ratio (OR) and 95 …
Association between the PARP1 Val762Ala polymorphism and cancer risk: evidence from 43 studies.
HRX Hua RuiXi, LHP Li HePing, LYB Liang YanBing… - 2014 - cabidigitallibrary.org
Abstract Background: Poly (ADP-ribose) polymerase-1 (PARP-1) plays critical roles in the
detection and repair of damaged DNA, as well as cell proliferation and death. Numerous
studies have examined the associations between PARP1 Val762Ala (rs1136410 T> C)
polymorphism and cancer susceptibility; nevertheless, the findings from different research
groups remain controversial. Methods: We searched literatures from MEDLINE, EMBASE
and CBM pertaining to such associations, and then calculated pooled odds ratio (OR) and …
detection and repair of damaged DNA, as well as cell proliferation and death. Numerous
studies have examined the associations between PARP1 Val762Ala (rs1136410 T> C)
polymorphism and cancer susceptibility; nevertheless, the findings from different research
groups remain controversial. Methods: We searched literatures from MEDLINE, EMBASE
and CBM pertaining to such associations, and then calculated pooled odds ratio (OR) and …
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