Association of apolipoprotein B–containing lipoproteins and risk of myocardial infarction in individuals with and without atherosclerosis: distinguishing between …
NA Marston, RP Giugliano, GEM Melloni… - JAMA …, 2022 - jamanetwork.com
Importance Lipid management typically focuses on levels of low-density lipoprotein
cholesterol (LDL-C) and, to a lesser extent, triglycerides (TG). However, animal models and
genetic studies suggest that the atherogenic particle subpopulations (LDL and very-low-
density lipoprotein [VLDL]) are both important and that the number of particles is more
predictive of cardiac events than their lipid content. Objective To determine whether common
measures of cholesterol concentration, TG concentration, or their ratio are associated with …
cholesterol (LDL-C) and, to a lesser extent, triglycerides (TG). However, animal models and
genetic studies suggest that the atherogenic particle subpopulations (LDL and very-low-
density lipoprotein [VLDL]) are both important and that the number of particles is more
predictive of cardiac events than their lipid content. Objective To determine whether common
measures of cholesterol concentration, TG concentration, or their ratio are associated with …
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