Association of diabetes and PNPLA3 genetic variants with disease severity of patients with chronic hepatitis C virus infection

CF Huang, CY Dai, ML Yeh, CI Huang, CM Tai… - Journal of …, 2015 - Elsevier
Background & Aims Genetic variants of patatin-like phospholipase domain-containing 3
(PNPLA3) and diabetes are associated with liver disease severity, in patients with chronic
hepatitis C (CHC) infection. We aimed at exploring their interaction in determining hepatitis
C virus (HCV)-related liver fibrosis. Methods The PNPLA3 genetic polymorphism at
rs738409 was verified in 1077 biopsy-proven CHC patients. Other clinical variables,
including diabetes status, were analysed for factors associated with bridging fibrosis …

Association of diabetes and PNPLA3 genetic variants with disease severity of patients with chronic hepatitis C virus infection.

HCF Huang ChungFeng, DCY Dai ChiaYen… - 2015 - cabidigitallibrary.org
Abstract Background & Aims: Genetic variants of patatin-like phospholipase domain-
containing 3 (PNPLA3) and diabetes are associated with liver disease severity, in patients
with chronic hepatitis C (CHC) infection. We aimed at exploring their interaction in
determining hepatitis C virus (HCV)-related liver fibrosis. Methods: The PNPLA3 genetic
polymorphism at rs738409 was verified in 1077 biopsy-proven CHC patients. Other clinical
variables, including diabetes status, were analysed for factors associated with bridging …
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