… the GAPD association further. We hypothesized that variation in other GAPD family members
may … may be important in determining an individual's risk for disease. Two functional GAPD …

… Alzheimer's disease (AD) is the most common form of dementia, affects an estimated 5.3
million people … explained by known GWAS SNPs with the strongest evidence for association …

… was 2.2% (R 2 = 0.242), together accounting for approximately 5.6% of genetic variation in
… effect modifiers enriched in families with multiple affected members. APOE-related survival …

… gene sets were enriched for genetic Alzheimer’s associations: … pathway member genes show
stronger Alzheimer’s disease … pathway signals to late-onset Alzheimer's disease. A positive …

… complex interactions between different genetic variants, age, gender… with two or more affected
people within more than one … the SNPs association with LOAD in different genetic models. …

… five studies with people with late-onset Alzheimer’s disease [5] … and the University of Pittsburgh
Alzheimer Disease Research Center (… Top genetic associations from each subgroup were …

… a new genetic finding for late-onset Alzheimer's disease (… reproducible significance of the
association of the Translocase of … that the age of disease onset for both of these people was 78 …

… novel genetic variants that predispose to LOAD, we performed SNP-based association …
240 bp, map to cathepsin S and a gene in the thioesterase superfamily member 5 (THEMS), …

… We confirmed association of APOE variants with age-at-… for approximately 4.1% of genetic
variation in AAO (R 2 =0.229)… enriched in families with multiple affected members. APOE-…

… People experiencing AD before the age of 60 are generally placed in the early-onset …
significant association of APOE genetic variation with cholesterol levels and coronary artery disease…