Association of late-onset Alzheimer's disease with genetic variation in multiple members of the GAPD gene family
… the GAPD association further. We hypothesized that variation in other GAPD family members
may … may be important in determining an individual's risk for disease. Two functional GAPD …
may … may be important in determining an individual's risk for disease. Two functional GAPD …
Assessment of the genetic variance of late-onset Alzheimer's disease
… Alzheimer's disease (AD) is the most common form of dementia, affects an estimated 5.3
million people … explained by known GWAS SNPs with the strongest evidence for association …
million people … explained by known GWAS SNPs with the strongest evidence for association …
Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study
… was 2.2% (R 2 = 0.242), together accounting for approximately 5.6% of genetic variation in
… effect modifiers enriched in families with multiple affected members. APOE-related survival …
… effect modifiers enriched in families with multiple affected members. APOE-related survival …
Genetic variation within endolysosomal system is associated with late-onset Alzheimer's disease
… gene sets were enriched for genetic Alzheimer’s associations: … pathway member genes show
stronger Alzheimer’s disease … pathway signals to late-onset Alzheimer's disease. A positive …
stronger Alzheimer’s disease … pathway signals to late-onset Alzheimer's disease. A positive …
Genetic factors affecting late-onset Alzheimer's disease susceptibility
M Rezazadeh, A Khorrami, T Yeghaneh… - Neuromolecular …, 2016 - Springer
… complex interactions between different genetic variants, age, gender… with two or more affected
people within more than one … the SNPs association with LOAD in different genetic models. …
people within more than one … the SNPs association with LOAD in different genetic models. …
Genetic data and cognitively defined late-onset Alzheimer's disease subgroups
… five studies with people with late-onset Alzheimer’s disease [5] … and the University of Pittsburgh
Alzheimer Disease Research Center (… Top genetic associations from each subgroup were …
Alzheimer Disease Research Center (… Top genetic associations from each subgroup were …
Genetic variation at a single locus and age of onset for Alzheimer's disease
MW Lutz, DG Crenshaw, AM Saunders… - Alzheimer's & Dementia, 2010 - Elsevier
… a new genetic finding for late-onset Alzheimer's disease (… reproducible significance of the
association of the Translocase of … that the age of disease onset for both of these people was 78 …
association of the Translocase of … that the age of disease onset for both of these people was 78 …
Evidence for novel susceptibility genes for late-onset Alzheimer's disease from a genome-wide association study of putative functional variants
… novel genetic variants that predispose to LOAD, we performed SNP-based association …
240 bp, map to cathepsin S and a gene in the thioesterase superfamily member 5 (THEMS), …
240 bp, map to cathepsin S and a gene in the thioesterase superfamily member 5 (THEMS), …
[HTML][HTML] Age-at-onset in late onset Alzheimer disease is modified by multiple genetic loci
… We confirmed association of APOE variants with age-at-… for approximately 4.1% of genetic
variation in AAO (R 2 =0.229)… enriched in families with multiple affected members. APOE-…
variation in AAO (R 2 =0.229)… enriched in families with multiple affected members. APOE-…
Molecular genetics of late‐onset Alzheimer's disease
MI Kamboh - Annals of human genetics, 2004 - Wiley Online Library
… People experiencing AD before the age of 60 are generally placed in the early-onset …
significant association of APOE genetic variation with cholesterol levels and coronary artery disease…
significant association of APOE genetic variation with cholesterol levels and coronary artery disease…