Abstract Background and Purpose Associations between dose and rectal toxicity in prostate
radiotherapy are generally poorly understood. Evaluating spatial dose distributions to the
rectal wall (RW) may lead to improvements in dose-toxicity modelling by incorporating
geometric information, masked by dose-volume histograms. Furthermore, predictive power
may be strengthened by incorporating the effects of interfraction motion into delivered dose
calculations. Here we interrogate 3D dose distributions for patients with and without toxicity …