Astaxanthin protects PC12 cells from glutamate-induced neurotoxicity through multiple signaling pathways
Astaxanthin, a carotenoid extensively found in marine organisms and increasingly used as a
dietary supplement, has been reported to have neuroprotective effect. In this study, the
neuroprotective effects and mechanisms of astaxanthin against glutamate-induced
neurotoxicity were explored. The results showed that pretreatment with astaxanthin inhibited
neuronal PC12 cell death induced by L-glutamate and reduced the production of reactive
oxygen species (ROS) significantly. Astaxanthin prevented glutamate-induced apoptosis by …
dietary supplement, has been reported to have neuroprotective effect. In this study, the
neuroprotective effects and mechanisms of astaxanthin against glutamate-induced
neurotoxicity were explored. The results showed that pretreatment with astaxanthin inhibited
neuronal PC12 cell death induced by L-glutamate and reduced the production of reactive
oxygen species (ROS) significantly. Astaxanthin prevented glutamate-induced apoptosis by …
Astaxanthin protects PC12 cells from glutamate-induced neurotoxicity through multiple signaling pathways.
ZYR Zhang YiRan, WW Wang Wei, HC Hao Cui… - 2015 - cabidigitallibrary.org
Astaxanthin, a carotenoid extensively found in marine organisms and increasingly used as a
dietary supplement, has been reported to have neuroprotective effect. In this study, the
neuroprotective effects and mechanisms of astaxanthin against glutamate-induced
neurotoxicity were explored. The results showed that pretreatment with astaxanthin inhibited
neuronal PC12 cell death induced by L-glutamate and reduced the production of reactive
oxygen species (ROS) significantly. Astaxanthin prevented glutamate-induced apoptosis by …
dietary supplement, has been reported to have neuroprotective effect. In this study, the
neuroprotective effects and mechanisms of astaxanthin against glutamate-induced
neurotoxicity were explored. The results showed that pretreatment with astaxanthin inhibited
neuronal PC12 cell death induced by L-glutamate and reduced the production of reactive
oxygen species (ROS) significantly. Astaxanthin prevented glutamate-induced apoptosis by …