Autophagy protects against aminochrome-induced cell death in substantia nigra-derived cell line
I Paris, P Munoz, S Huenchuguala… - Toxicological …, 2011 - academic.oup.com
Aminochrome, the precursor of neuromelanin, has been proposed to be involved in the
neurodegeneration neuromelanin-containing dopaminergic neurons in Parkinson's disease.
We aimed to study the mechanism of aminochrome-dependent cell death in a cell line
derived from rat substantia nigra. We found that aminochrome (50μM), in the presence of
NAD (P) H-quinone oxidoreductase, EC 1.6. 99.2 (DT)-diaphorase inhibitor dicoumarol
(DIC)(100μM), induces significant cell death (62±3%; p< 0.01), increase in caspase-3 …
neurodegeneration neuromelanin-containing dopaminergic neurons in Parkinson's disease.
We aimed to study the mechanism of aminochrome-dependent cell death in a cell line
derived from rat substantia nigra. We found that aminochrome (50μM), in the presence of
NAD (P) H-quinone oxidoreductase, EC 1.6. 99.2 (DT)-diaphorase inhibitor dicoumarol
(DIC)(100μM), induces significant cell death (62±3%; p< 0.01), increase in caspase-3 …
Autophagy protects against aminochrome-induced cell death in substantia nigra-derived cell line
I Paris Pizarro, P Muñoz, S Huenchuguala, E Couve… - 2011 - repositorio.uchile.cl
Aminochrome, the precursor of neuromelanin, has been proposed to be involved in the
neurodegeneration neuromelanincontaining dopaminergic neurons in Parkinson's disease.
We aimed to study the mechanism of aminochrome-dependent cell death in a cell line
derived from rat substantia nigra. We found that aminochrome (50μM), in the presence of
NAD (P) H-quinone oxidoreductase, EC 1.6. 99.2 (DT)-diaphorase inhibitor dicoumarol
(DIC)(100μM), induces significant cell death (62±3%; p< 0.01), increase in caspase-3 …
neurodegeneration neuromelanincontaining dopaminergic neurons in Parkinson's disease.
We aimed to study the mechanism of aminochrome-dependent cell death in a cell line
derived from rat substantia nigra. We found that aminochrome (50μM), in the presence of
NAD (P) H-quinone oxidoreductase, EC 1.6. 99.2 (DT)-diaphorase inhibitor dicoumarol
(DIC)(100μM), induces significant cell death (62±3%; p< 0.01), increase in caspase-3 …
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