Autophagy is a vital process that involves degradation of long-lived proteins and
dysfunctional organelles and contributes to cellular metabolism. Glioma-initiating cells
(GICs) have the ability to self-renew, differentiate into heterogeneous types of tumor cells,
and sustain tumorigenicity; thus, GICs lead to tumor recurrence. Accumulating evidence
indicates that autophagy can induce stem cell differentiation and increase the lethality of
temozolomide against GICs. However, the mechanism underlying the regulation of GIC self …