B cell signaling in context

K Kwak, M Akkaya, SK Pierce - Nature immunology, 2019 - nature.com
… However, although the potential of the BCR to orchestrate B cell behavior … context in which
B cells signal in secondary lymphoid organs in vivo or how that context influences signaling. …

Bcell stage and context‐dependent requirements for survival signals from BAFF and the Bcell receptor

F Mackay, WA Figgett, D Saulep… - Immunological …, 2010 - Wiley Online Library
… to activate them, it is unclear how TACI normally facilitates this process at the signaling level.
Our understanding of BAFF-mediated cell signaling has progressed significantly in recent …

The cellular context of T cell signaling

ML Dustin - Immunity, 2009 - cell.com
… Early work on the T cell signaling response to TCR-MHC-peptide interactions revealed rapid
… The specific interaction of helper T cells and antigen-presenting B cells. IV. Membrane and …

B cell antigen receptor signaling 101

JM Dal Porto, SB Gauld, KT Merrell, D Mills… - Molecular …, 2004 - Elsevier
… with antigen can alter the B cell signal processing. While signal termination and feedback …
stage of the B cell, its microenvironment, the physical form and/or context of the Ag and the …

Tonic Bcell and viral ITAM signaling: context is everything

SM Grande, G Bannish… - Immunological …, 2007 - Wiley Online Library
… In this review, we discuss what is known about tonic signaling by both cellular and viral
ITAM-containing proteins and speculate what we might learn from each context. …

B cell responses: cell interaction dynamics and decisions

JG Cyster, CDC Allen - Cell, 2019 - cell.com
… about B cells and much work to be done. In this review, we give an overview of how B cells
… -, or IgE-secreting plasma cells (PCs) or memory B (Bmem) cells, and how they contribute to …

Cell signaling regulation by protein phosphorylation: a multivariate, heterogeneous, and context-dependent process

EK Day, NG Sosale, MJ Lazzara - Current opinion in biotechnology, 2016 - Elsevier
… multiple signaling pathways … cellular phenotypes; the tendency for cell signaling processes
to occur heterogeneously among cells in populations; and the ability of the local cell context (…

The lymph node microenvironment promotes B-cell receptor signaling, NF-κB activation, and tumor proliferation in chronic lymphocytic leukemia

…, D Liu, A Biancotto, S Pittaluga, B Vire… - Blood, The Journal …, 2011 - ashpublications.org
… CLL cells of both subtypes and normal naive B cells showed … between CLL cells of either
subtype and normal B cells. However, … in the context of positive selection of a precursor cell, as …

Regulation of B-cell fate by antigen-receptor signals

H Niiro, EA Clark - Nature Reviews Immunology, 2002 - nature.com
… T cells, that are important for B-cell fate decisions. Moreover, BCR signalling is integrated by
adaptors in B cells and fine-tuned by co-receptors on B cells. … strength and context of BCR …

Signaling pathways in context

F Uschner, E Klipp - Current opinion in biotechnology, 2019 - Elsevier
… Although there exist many different important steps and considerations toward the
integration of signaling into comprehensive cellular context, we highlight three scopes of such …