B1 and B2 kinin receptor participation in hyperproliferative and inflammatory skin processes in mice
EF Pietrovski, KS Paludo, DAGB Mendes… - Journal of …, 2011 - Elsevier
BACKGROUND: Kinins are released during dermal injury and inflammation and seem to
contribute to the pathogenesis of cutaneous diseases. OBJECTIVE: Participation of kinins in
skin inflammatory process was evaluated using knockout mice and non-peptide kinin
receptor antagonists. METHODS: Chronic skin inflammation was induced by multiple
applications of TPA in mice ear. RESULTS: The B2 knockout mice (B2−/−) showed a
significant increase of ear weight (23±10%) and epidermal cellular hyperproliferation and …
contribute to the pathogenesis of cutaneous diseases. OBJECTIVE: Participation of kinins in
skin inflammatory process was evaluated using knockout mice and non-peptide kinin
receptor antagonists. METHODS: Chronic skin inflammation was induced by multiple
applications of TPA in mice ear. RESULTS: The B2 knockout mice (B2−/−) showed a
significant increase of ear weight (23±10%) and epidermal cellular hyperproliferation and …