BECLIN1 is essential for intestinal homeostasis involving autophagy-independent mechanisms through its function in endocytic trafficking

S Tran, J Juliani, TJ Harris, M Evangelista… - Communications …, 2024 - nature.com
… mediated by BECLIN1 and loss of intestinal barrier integrity. … of BECLIN1 in maintaining
mammalian intestinal homeostasis … has important implications for our understanding of intestinal

How autophagy controls the intestinal epithelial barrier

EG Foerster, T Mukherjee, L Cabral-Fernandes… - Autophagy, 2022 - Taylor & Francis
… AMBRA1: autophagy and beclin 1 regulator 1; NRBF2: … of intestinal homeostasis during
stress [Citation81]. … autophagy-independent mechanism of ATG5 or an extra-tumoral response is …

[PDF][PDF] BECLIN1 is essential for intestinal homeostasis involving autophagy-independent mechanisms through its function in endocytic trafficking

SL Ellis, D Baloyan, CM Reehorst, R Nightingale… - scholar.archive.org
… mediated by BECLIN1 and loss of intestinal barrier integrity. … of BECLIN1 in maintaining
mammalian intestinal homeostasis … has important implications for our understanding of intestinal

Intestinal epithelial tight junction barrier regulation by autophagy-related protein ATG6/beclin 1

M Wong, AS Ganapathy, E Suchanec… - … of Physiology-Cell …, 2019 - journals.physiology.org
… Our data show that beclin 1 plays an autophagy-independent role in the constitutive … The
intestinal epithelial TJ barrier is a crucial determinant of intestinal homeostasis. A defective …

How autophagy, a potential therapeutic target, regulates intestinal inflammation

SL Chen, CM Li, W Li, QS Liu, SY Hu, MY Zhao… - Frontiers in …, 2023 - frontiersin.org
… is pivotal for intestinal homeostasis maintenance, gut ecology … Beclin-1 and phosphorylation
of Beclin-1 (81), which is a … classes, and the autophagy-independent effects. Therefore, …

The role of Beclin 1-dependent autophagy in cancer

S Vega-Rubín-de-Celis - Biology, 2019 - mdpi.com
… Interestingly, S90 phosphorylation is essential for the Beclin 1Beclin 1-tyrosine
phosphorylation-independent mechanism [… with autophagy, Beclin 1 autophagy-independent

Beclin-1: a therapeutic target at the intersection of autophagy, immunotherapy, and cancer treatment

Z Cao, K Tian, Y Ran, H Zhou, L Zhou, Y Ding… - Frontiers in …, 2024 - frontiersin.org
Beclin-1’s vital role in controlling autophagy, its influence on cancer growth, drug resistance,
and interactions with cell death mechanisms… in both autophagyindependent and autophagy-…

BECLIN1 is essential for intestinal homeostasis

E Lee, S Tran, J Juliani, T Harris, M Evangelista… - 2023 - researchsquare.com
autophagy-independent 94 mechanisms, likely caused by defective endocytic trafficking.
95 … of 153 intestinal homeostasis. We postulate that its autophagy-independent function in …

Autophagy and intestinal homeostasis

KK Patel, TS Stappenbeck - Annual review of physiology, 2013 - annualreviews.org
… dependent and autophagy-independent mechanisms. Recently… B cells also play an important
role in intestinal homeostasis … Additionally, Beclin 1 is essential for the development of both …

Autophagy reduces the degradation and promotes membrane localization of occludin to enhance the intestinal epithelial tight junction barrier against paracellular …

K Saha, A Subramenium Ganapathy… - Journal of Crohn's …, 2023 - academic.oup.com
… permeability of the gut epithelium is a key factor determining … endocytic processes in tightly
controlled mechanisms, 6,7 and … the autophagy-independent role of the Atg6/Beclin-1 protein …