BTG1 mutation yields supercompetitive B cells primed for malignant transformation

C Mlynarczyk, M Teater, J Pae, CR Chin, L Wang… - Science, 2023 - science.org
Multicellular life requires altruistic cooperation between cells. The adaptive immune system
is a notable exception, wherein germinal center B cells compete vigorously for limiting
positive selection signals. Studying primary human lymphomas and developing new mouse
models, we found that mutations affecting BTG1 disrupt a critical immune gatekeeper
mechanism that strictly limits B cell fitness during antibody affinity maturation. This
mechanism converted germinal center B cells into supercompetitors that rapidly outstrip their …

[引用][C] BTG1 mutation yields supercompetitive B cells primed for malignant transformation. Science 379, eabj7412

C Mlynarczyk, M Teater, J Pae, CR Chin, L Wang… - 2023
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