Barcoded viral tracing of single-cell interactions in central nervous system inflammation
INTRODUCTION Glial cells of the central nervous system (CNS), including astrocytes and
microglia, play critical roles in development, tissue repair, and homeostasis. However,
dysregulated astrocyte and microglia responses contribute to the pathogenesis of
neurologic diseases. Indeed, environmental chemicals, microbial metabolites, and cell-cell
interactions have been shown to modulate disease-promoting responses in astrocytes and
microglia in the context of multiple sclerosis (MS) and its model, experimental autoimmune …
microglia, play critical roles in development, tissue repair, and homeostasis. However,
dysregulated astrocyte and microglia responses contribute to the pathogenesis of
neurologic diseases. Indeed, environmental chemicals, microbial metabolites, and cell-cell
interactions have been shown to modulate disease-promoting responses in astrocytes and
microglia in the context of multiple sclerosis (MS) and its model, experimental autoimmune …
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