… long-term use of melatonin in the elderly despite its low side effect profile and low potential
for abuse. These concerns also stem from inappropriate dosing and use in specific clinical …

… Use of melatonin for novel … safety of melatonin to date. In response, we conducted a
systematic review of available evidence relating to adverse effects of orally-administered melatonin. …

… found in aging. This review focuses on the advantages and disadvantages of utilizing melatonin
to … However, adverse effects of hypnotics are more prevalent in the elderly due both to …

… use. There are several factors which increase the risk of adverse effects of melatonin in older
adults, … Citation8 Therapeutic strategies taking advantage of the diverse effects of melatonin …

… benefits marginally outweigh its harms, with limited to no consistent evidence of adverse
events … the documented marginal efficacy and potential adverse effects of melatonin (as well as …

… The rate of adverse events normalized per 100 patient-weeks was lower for PRM (3.66) …
of overall benefit to the patients. The CGI rating scales are commonly used measures of …

… that melatonin may greatly benefit aging individuals given its relatively safe profile, potential
anti-aging effects, … by caregivers; adverse reaction to melatonin therapy and development of …

… Citation2 This indicates that falls in older people must be … Falls are considered alarming
adverse events due to their … Citation7 Falls are adverse events that affect older people not …

… in an older population, and all have considerable adverse effects. … Valerian and melatonin
are unregulated products that have a small … In individuals aged >60 years, the benefits of …

… with an increased risk of adverse events such as physical … and amount of sleep, these
benefits are outweighed by the … number of subjects receiving melatonin receptor agonists may …