Berberine inhibits enterovirus 71 replication by downregulating the MEK/ERK signaling pathway and autophagy

H Wang, K Li, L Ma, S Wu, J Hu, H Yan, J Jiang, Y Li - Virology journal, 2017 - Springer
… to have ability to regulate this signaling pathway and autophagy. Herein, we want to determine
berberine can inhibit EV71 infection by downregulating the MEK/ERK signaling pathway

Synthesis and evolution of berberine derivatives as a new class of antiviral agents against enterovirus 71 through the MEK/ERK pathway and autophagy

YX Wang, L Yang, HQ Wang, XQ Zhao, T Liu, YH Li… - Molecules, 2018 - mdpi.com
signaling pathway. We can conclude that compound 2d inhibited the replication of EV71
through down-regulating MEK/ERK signaling pathway. …

Antiviral activity of berberine

A Warowicka, R Nawrot, A Goździcka-Józefiak - Archives of virology, 2020 - Springer
… BBR also inhibits the MEK/ERK signaling pathway, which is … against different genotypes
of enterovirus 71 (EV71), which … downregulation of MEK/ERK signaling, inhibition of EV71-…

Berberine hampers influenza a replication through inhibition of MAPK/ERK pathway

P Botwina, K Owczarek, Z Rajfur, M Ochman, M Urlik… - Viruses, 2020 - mdpi.com
… BBR inhibits the influenza A virus through downregulation of … of the Chikungunya virus
(CHIKV) and the enterovirus 71, … MAPK) signaling pathways, including extracellular signal-related …

Berberine prevents lethal EV71 neurological infection in newborn mice

G Cui, H Wang, C Yang, X Zhou, J Wang… - Frontiers in …, 2022 - frontiersin.org
Enterovirus 71 (EV71) is the major pathogen causing fatal neurological complications of …
for the first time that BBR strongly inhibited EV71 replication in neural cells and prevented lethal …

[HTML][HTML] A small molecule compound berberine as an orally active therapeutic candidate against COVID‐19 and SARS: A computational and mechanistic study

ZZ Wang, K Li, AR Maskey, W Huang… - The FASEB …, 2021 - ncbi.nlm.nih.gov
… was shown to mitigate inflammatory cytokine production by downregulation of MAP … Berberine
has been found to hamper influenza A and enterovirus 71 replication through inhibition of …

Antiviral Activity of Rhein against Enterovirus 71 through Inhibiting Viral Replication and Stability

ZZ Lai, HC Yang, YM Lee - Journal of Medical Sciences, 2024 - journals.lww.com
… that rhein may inhibit EV71 replication by inhibiting ERK signaling. … EV71 replication. A
putative mechanism is proposed that rhein likely inhibits EV71 replication via the downregulation

Autophagy induced by enterovirus 71 regulates the production of IL-6 through the p38MAPK and ERK signaling pathways

L Cao, X Zhang, S Yuan, K Cheng, X Zhang - Microbial Pathogenesis, 2019 - Elsevier
… [11] have found that EV71 infection induced changes in the MEK/ERK signalingberberine,
an isoquinoline alkaloid isolated from Berberis vulgaris L., inhibited the replication of EV71. …

Berberine inhibits dengue virus through dual mechanisms

T Ratanakomol, S Roytrakul, N Wikan, DR Smith - Molecules, 2021 - mdpi.com
… ), enterovirus 71 and respiratory syncytial virus infections [15,16,17,18], and through inhibition
of … impact how berberine affects viral replication, or its effects in other disease processes. …

In Vitro Inhibitory Effect of Berberine Against Rotavirus

HT Nguyen, TN Hoa‐Tran, HQ Tran… - Chemistry & … - Wiley Online Library
Berberine inhibits enterovirus 71 replication by downregulating the MEK/ERK signaling
pathway … , 'The isoquinoline alkaloid berberine inhibits human cytomegalovirus replication by …