Metformin displays antileukemic effects partly due to activation of AMPK and subsequent
inhibition of mTOR signaling. Nevertheless, Metformin also inhibits mitochondrial electron
transport at complex I in an AMPK-independent manner, Here we report that Metformin and
rotenone inhibit mitochondrial electron transport and increase triglyceride levels in leukemia
cell lines, suggesting impairment of fatty acid oxidation (FAO). We also report that, like other
FAO inhibitors, both agents and the related biguanide, Phenformin, increase sensitivity to …