[HTML][HTML] Binding of Anti-Cell Adhesive Oxime-Crosslinked PEG Hydrogels to Cardiac Tissues
GN Grover, J Garcia, MM Nguyen… - Advanced healthcare …, 2015 - ncbi.nlm.nih.gov
Advanced healthcare materials, 2015•ncbi.nlm.nih.gov
Post-surgical cardiac adhesions increase surgery times as well as patient mortality and
morbidity. We present a fast gelling oxime-crosslinked PEG hydrogel with tunable gelation
time, degradation, and mechanical properties. This material is cytocompatible and prevents
cellular adhesion. We demonstrate material retention on different cardiac tissues ex vivo
over time and that functional group ratio alters material retention on different cardiac tissues.
morbidity. We present a fast gelling oxime-crosslinked PEG hydrogel with tunable gelation
time, degradation, and mechanical properties. This material is cytocompatible and prevents
cellular adhesion. We demonstrate material retention on different cardiac tissues ex vivo
over time and that functional group ratio alters material retention on different cardiac tissues.
Post-surgical cardiac adhesions increase surgery times as well as patient mortality and morbidity. We present a fast gelling oxime-crosslinked PEG hydrogel with tunable gelation time, degradation, and mechanical properties. This material is cytocompatible and prevents cellular adhesion. We demonstrate material retention on different cardiac tissues ex vivo over time and that functional group ratio alters material retention on different cardiac tissues.
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