An injectable biodegradable hydrogel system based on oligo (amidoamine/β-amino
ester)(OAAAE) was designed and synthesized for controlled release of insulin under the
physiological conditions. OAAAE was prepared in one step via the Michael-addition
oligomerization of the secondary amine groups of 4, 4-trimethylene dipiperidine (TMDP) with
the vinyl groups of 1, 8-octylene diacrylamide (ODA) and 1, 6-hexane diol diacrylate (HDA).
The formed oligomer was characterized by 1H NMR and gel permeation chromatography …

… Huynh Cong Truc, 이두성† 성균관대학교 A novel hydrogel system using oligo(amido
amine/β-amino ester) (OAAAE) was synthesized for controlled release of insulin. OAAAE
was prepared by the Michaeladdition oligomerization of the secondary amine groups of 4,4-trimethylene
dipiperidine with the vinyl groups of 1,8-octylene diacrylamide and 1,6-hexanediol diacrylate.
The formed oligomer was characterized by 1H NMR and gel permeation chromatography. …
The degradation of the hydrogel, influence of insulin on gel phase and gel strength, in vitro …