Bioinspired Synthesis of Platensimycin from Natural ent-Kaurenoic Acids
Á Pérez, JF Quílez del Moral, A Galisteo… - Organic …, 2023 - ACS Publications
The biomimetic formal synthesis of the antibiotic platensimycin for the treatment of infection
by multidrug-resistant bacteria was accomplished starting from either ent-kaurenoic acid or
grandiflorenic acid, each of which is a natural compound available in multigram scale from
its natural source. Apart from the natural origin of the selected precursors, the keys of the
described approach are the long-distance functionalization of ent-kaurenoic acid at C11 and
the efficient protocol for the A-ring degradation of the diterpene framework.
by multidrug-resistant bacteria was accomplished starting from either ent-kaurenoic acid or
grandiflorenic acid, each of which is a natural compound available in multigram scale from
its natural source. Apart from the natural origin of the selected precursors, the keys of the
described approach are the long-distance functionalization of ent-kaurenoic acid at C11 and
the efficient protocol for the A-ring degradation of the diterpene framework.
[PDF][PDF] Bioinspired Synthesis of Platensimycin from Natural ent-Kaurenoic Acids
ÁA Pérez Rodríguez, JF Quílez Del Moral… - 2023 - digibug.ugr.es
The biomimetic formal synthesis of the antibiotic platensimycin for the treatment of infection
by multidrug-resistant bacteria was accomplished starting from either ent-kaurenoic acid or
grandiflorenic acid, each of which is a natural compound available in multigram scale from
its natural source. Apart from the natural origin of the selected precursors, the keys of the
described approach are the long-distance functionalization of ent-kaurenoic acid at C11 and
the efficient protocol for the A-ring degradation of the diterpene framework.
by multidrug-resistant bacteria was accomplished starting from either ent-kaurenoic acid or
grandiflorenic acid, each of which is a natural compound available in multigram scale from
its natural source. Apart from the natural origin of the selected precursors, the keys of the
described approach are the long-distance functionalization of ent-kaurenoic acid at C11 and
the efficient protocol for the A-ring degradation of the diterpene framework.
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