… risk assessment. For as long as Chemical Research in Toxicology has been published, we
have used biomarkers … use such biomarkers of exposure to also inform risk assessment, since …

… the molecular dose of DNA and protein adducts, the relationships between macromolecular
… biomarkers have in cancer risk assessment. The paper uses a framework analysis approach …

… –response relationships for quantitative risk assessment. … of a dose effect. Issues to consider
include the persistence of … and toxicological processes to better inform risk assessments, …

… ongoing processes to better inform risk assessments [14, 15]. … risk assessment are studies
which examined the relationship … , with evidence of a dose effect. The value of these data for …

… of their ability to inform risk assessments. For example… biomarker for a putative KE such as
enzyme induction indicates that exploring the quantitative relationship between this biomarker …

… for application in risk assessment strategies. While proof of … characterization, dose response,
and risk characterization … trends of in vivo dose-response relationships is for biomarkers of …

… relationship could be described as a linear dose response. … dose-response for mutations
may be useful as a biomarker … data have greatly informed mode of action analysis for Cr(VI). …

… , preclinical safety evaluation, risk assessment, and biomarkers (Fig… desired concentrations
due to PK or toxicity profiles. The … is critical when informing dose selection using a biomarker. …

… dose-response relationship, early indicators of increased risk of an adverse effect (eg,
biomarkers … understanding into practical advances in risk assessment and public health decision-…

… environmental and occupational settings and risk assessment (2). … We analyzed the
dose-response relationships between … All study subjects provided a written informed consent …