Biomembrane models and drug-biomembrane interaction studies: Involvement in drug design and development

R Pignatello, T Musumeci, L Basile… - Journal of pharmacy …, 2011 - journals.lww.com
Contact with many different biological membranes goes along the destiny of a drug after its
systemic administration. From the circulating macrophage cells to the vessel endothelium, to
more complex absorption barriers, the interaction of a biomolecule with these membranes
largely affects its rate and time of biodistribution in the body and at the target sites.
Therefore, investigating the phenomena occurring on the cell membranes, as well as their
different interaction with drugs in the physiological or pathological conditions, is important to …
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