The development of new therapeutic approaches that aim to help the body exert its natural
mechanisms for vascularized tissue growth (therapeutic angiogenesis) has become one of
the most active areas of tissue engineering. Through basic research, several growth factor
families and cytokines that are capable to induce physiological blood vessel formation have
been identified. Indeed, preclinical and clinical investigations have indicated that therapeutic
administration of angiogenic factors, such as the prototypic vascular endothelial growth …