Bioprinting of patient-derived in vitro intrahepatic cholangiocarcinoma tumor model: establishment, evaluation and anti-cancer drug testing
S Mao, J He, Y Zhao, T Liu, F Xie, H Yang, Y Mao… - …, 2020 - iopscience.iop.org
Towards the development of in vivo-mimicking tumor model for extensive study of
tumorigenesis and establishment of personalized therapy, patient-derived primary tumor
cells were employed in this work for three-dimensional (3D) bioprinting. Intrahepatic
cholangiocarcinoma cells isolated from patient were bioprinted using a composite hydrogel
system of gelatin-alginate-Matrigel TM into pre-designed grid architecture. ICC cells were
observed to process a colony forming ability with high survival rate and active proliferation …
tumorigenesis and establishment of personalized therapy, patient-derived primary tumor
cells were employed in this work for three-dimensional (3D) bioprinting. Intrahepatic
cholangiocarcinoma cells isolated from patient were bioprinted using a composite hydrogel
system of gelatin-alginate-Matrigel TM into pre-designed grid architecture. ICC cells were
observed to process a colony forming ability with high survival rate and active proliferation …
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