An inverse relationship between brain serotonin and food intake and body weight has been
known for more than 30years. Specifically, augmentation of brain serotonin inhibits food
intake, while depletion of brain serotonin promotes hyperphagia and weight gain. Through
the decades, serotonin receptors have been identified and their function in the serotonergic
regulation of food intake clarified. Recent refined genetic studies now indicate that a primary
mechanism through which serotonin influences appetite and body weight is via serotonin 2C …