[HTML][HTML] Breaking the barrier: an osmium photosensitizer with unprecedented hypoxic phototoxicity for real world photodynamic therapy
Hypoxia presents a two-fold challenge in the treatment of cancer, as low oxygen conditions
induce biological changes that make malignant tissues simultaneously more aggressive and
less susceptible to standard chemotherapy. This paper reports the first metal-based
photosensitizer that approaches the ideal properties for a phototherapy agent. The Os
(phen) 2-based scaffold was combined with a series of IP-nT ligands, where phen= 1, 10-
phenanthroline and IP-nT= imidazo [4, 5-f][1, 10] phenanthroline tethered to n= 0–4 …
induce biological changes that make malignant tissues simultaneously more aggressive and
less susceptible to standard chemotherapy. This paper reports the first metal-based
photosensitizer that approaches the ideal properties for a phototherapy agent. The Os
(phen) 2-based scaffold was combined with a series of IP-nT ligands, where phen= 1, 10-
phenanthroline and IP-nT= imidazo [4, 5-f][1, 10] phenanthroline tethered to n= 0–4 …
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