Buspirone loaded solid lipid nanoparticles for amplification of nose to brain efficacy: Formulation development, optimization by Box-Behnken design, in-vitro …
The strategies to avoid blood brain barrier are been explored to improve brain targeting
therapeutics in order to ensure potential prospects of nose to brain delivery. In this research
work, Buspirone (BUS) loaded solid lipid nanoparticles (SLNs) for nose to brain delivery
were prepared by solvent free technique and optimized by three factors and three levels Box-
Behnken design. The three independent variables viz, drug (BUS) to lipid (Compritol® 888
ATO) ratio (labeled A), surfactant concentration (tween 80+ poloxamer, 2: 1-labeled B) and …
therapeutics in order to ensure potential prospects of nose to brain delivery. In this research
work, Buspirone (BUS) loaded solid lipid nanoparticles (SLNs) for nose to brain delivery
were prepared by solvent free technique and optimized by three factors and three levels Box-
Behnken design. The three independent variables viz, drug (BUS) to lipid (Compritol® 888
ATO) ratio (labeled A), surfactant concentration (tween 80+ poloxamer, 2: 1-labeled B) and …
[引用][C] Buspirone loaded solid lipid nanoparticles for amplification of nose to brain efficacy: Formulation development, optimization by Box-Behnken design, in-vitro …
M Yasir, I Chauhan, A Zafar, M Verma, KM Noorulla… - DOI: https://doi. org/10.1016 …, 2020
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