Butyrate and deoxycholic acid play common and distinct roles in HCT116 human colon cell proliferation
H Zeng, KJ Claycombe, KM Reindl - The Journal of nutritional biochemistry, 2015 - Elsevier
Consumption of a high-fat diet causes an increase in bile acid deoxycholic acid (DCA) in
colon lumen and colon cancer risk, while butyrate, an intestinal microbiota metabolite of
dietary fiber, has been shown to exhibit colon cancer-preventive effects. To distinguish these
opposing effects of DCA and butyrate (two major metabolites in colon lumen), we examined
the effects of physiologically relevant doses of butyrate (0.5–2 mmol/l) and DCA (0.05–0.3
mmol/l) on colon cell proliferation. We hypothesize that butyrate and DCA each modulates …
colon lumen and colon cancer risk, while butyrate, an intestinal microbiota metabolite of
dietary fiber, has been shown to exhibit colon cancer-preventive effects. To distinguish these
opposing effects of DCA and butyrate (two major metabolites in colon lumen), we examined
the effects of physiologically relevant doses of butyrate (0.5–2 mmol/l) and DCA (0.05–0.3
mmol/l) on colon cell proliferation. We hypothesize that butyrate and DCA each modulates …
Butyrate and deoxycholic acid play common and distinct roles in HCT116 human colon cell proliferation.
ZHW Zeng HuaWei, KJ Claycombe, KM Reindl - 2015 - cabidigitallibrary.org
Consumption of a high-fat diet causes an increase in bile acid deoxycholic acid (DCA) in
colon lumen and colon cancer risk, while butyrate, an intestinal microbiota metabolite of
dietary fiber, has been shown to exhibit colon cancer-preventive effects. To distinguish these
opposing effects of DCA and butyrate (two major metabolites in colon lumen), we examined
the effects of physiologically relevant doses of butyrate (0.5-2 mmol/l) and DCA (0.05-0.3
mmol/l) on colon cell proliferation. We hypothesize that butyrate and DCA each modulates …
colon lumen and colon cancer risk, while butyrate, an intestinal microbiota metabolite of
dietary fiber, has been shown to exhibit colon cancer-preventive effects. To distinguish these
opposing effects of DCA and butyrate (two major metabolites in colon lumen), we examined
the effects of physiologically relevant doses of butyrate (0.5-2 mmol/l) and DCA (0.05-0.3
mmol/l) on colon cell proliferation. We hypothesize that butyrate and DCA each modulates …
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