Recent advances in our understanding of the disease pathology of membranoproliferative
glomerulonephritis has resulted in its re-classification as complement C3 glomerulopathy (…

… with isolated subendothelial deposition of complement C3”. These lesions were often … of
C3 within the glomerulus in the absence of immunoglobulin. We suggest that 'C3 glomerulopathy…

… the art with regard to current understanding of C3 glomerulopathy. We present insights
relating to the histopathological diagnosis of C3 glomerulopathy and describe the crucial role of …

… glomerular C3 deposition with less marked or no effect on plasma C3 regulation. … C3 both
along the GBM (resulting in C3 glomerulopathy) and in the circulation (resulting in plasma C3 …

… characterized by C3 accumulation with … C3 glomerulopathy in the first C3 Glomerulopathy
Meeting. The objectives were to reach a consensus on: the definition of C3 glomerulopathy, …

… C3 glomerulopathies. We analyse current data about the pathogenesis of the two best
examples of C3 glomerulopathies—DDD and C3 … for the C3 glomerulopathies, including recent …

… renal biopsy findings in C3 glomerulopathy include a small … among patients with C3
glomerulopathy, we retrospectively … fulfilling pathologic criteria for C3 glomerulopathy. We …

… of C3 glomerulopathy, relating these to underlying molecular mechanisms. The role of
uncontrolled C3 … of individuals or families with C3 glomerulopathy are discussed. While no therapy …

… C3 proteins in C3 glomerulopathy based on LC-MS studies. Activation of C3 occurs via
cleavage of C3a from C3… The absence of C3a by mass spectrometry confirms activation of C3. …

… C3 and CFHR5 genes are associated with DDD and one at-risk MCP haplotype have been
found to be significantly increased in C3GN. C3 glomerulopathies … of complement C3 and C5 …