CGRP in animal models of migraine
AS Wattiez, M Wang, AF Russo - Calcitonin Gene-Related Peptide (CGRP …, 2019 - Springer
… animal models of migraine involve CGRP to some degree. The importance of CGRP in
those models is confirmed by the ability of direct injection of CGRP to induce several migraine-…
those models is confirmed by the ability of direct injection of CGRP to induce several migraine-…
Behavioral study of a rat model of migraine induced by CGRP
G Yao, Q Huang, M Wang, CL Yang, CF Liu, TM Yu - Neuroscience Letters, 2017 - Elsevier
… animal model of migraine induced by epidural injection of calcitonin gene-related peptide
(CGRP), … to establish a new animal model of migraine through epidural injection of CGRP. The …
(CGRP), … to establish a new animal model of migraine through epidural injection of CGRP. The …
Antagonism of CGRP receptor: central and peripheral mechanisms and mediators in an animal model of chronic migraine
R Greco, C Demartini, M Francavilla, AM Zanaboni… - Cells, 2022 - mdpi.com
… NTG-induced trigeminal hyperalgesia, we first tested two doses of the CGRP receptor
antagonist in the acute animal model of migraine on the basis of a single NTG (10 mg/kg, ip) …
antagonist in the acute animal model of migraine on the basis of a single NTG (10 mg/kg, ip) …
The role of the brainstem in migraine: Potential brainstem effects of CGRP and CGRP receptor activation in animal models
PR Holland, C Saengjaroentham… - Cephalalgia, 2019 - journals.sagepub.com
… brainstem as a key regulator of migraine biology and associated symptoms. We … CGRP in
the brainstem and its modulation for migraine therapy, given the emergence of targeted CGRP …
the brainstem and its modulation for migraine therapy, given the emergence of targeted CGRP …
[HTML][HTML] A potential preclinical migraine model: CGRP-sensitized mice
… migraine. However, a major challenge for studying CGRP actions is the lack of animal models
for migraine. … are more sensitive to CGRP than people who do not suffer from migraine. We …
for migraine. … are more sensitive to CGRP than people who do not suffer from migraine. We …
Animal models of chronic migraine
TM Chou, SP Chen - Current Pain and Headache Reports, 2018 - Springer
… A validated animal model could help to decipher the pathogenic mechanism of the disease,
… aimed to summarize current animal models of CM and discuss the validity of these models. …
… aimed to summarize current animal models of CM and discuss the validity of these models. …
Animal models of pain and migraine in drug discovery
… targeted to calcitonin-gene-related peptide (CGRP) and its … For CGRP, potential cardiac
liability issues have recently … Burden of Disease Study 2015 lists migraine at number five as a …
liability issues have recently … Burden of Disease Study 2015 lists migraine at number five as a …
Animal models of chronic migraine
RJ Storer, W Supronsinchai… - Current pain and headache …, 2015 - Springer
… that the CGRP pathway is crucial in migraine pathophysiology [45], it may be that simple
perturbation of meningeal and trigeminovascular nociceptors is sufficient to model migraine and …
perturbation of meningeal and trigeminovascular nociceptors is sufficient to model migraine and …
Animal migraine models for drug development: status and future perspectives
… animal models with ability to predict efficacy of anti-migraine … of CGRP and blocked by
co-administration of the CGRP … if migraine triggering substances other than CGRP are able …
co-administration of the CGRP … if migraine triggering substances other than CGRP are able …
Animal models of migraine and experimental techniques used to examine trigeminal sensory processing
AM Harriott, LC Strother, M Vila-Pueyo… - The journal of headache …, 2019 - Springer
… Animal models of migraine focused on trigeminal sensory processing have increased our
mechanistic understanding of migraine … of inhibiting CGRP signaling [8], the use of CGRP …
mechanistic understanding of migraine … of inhibiting CGRP signaling [8], the use of CGRP …
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