Context Given the probable importance of the α4 subunit of the neuronal nicotinic
acetylcholine receptor, the gene that codes for this subunit (CHRNA4) represents an
excellent starting point for a genetic investigation of smoking behavior. Objective To achieve
a better understanding of the role of this gene in the cause and treatment of tobacco
dependence, we adopted a transdisciplinary pharmacogenetic approach. Design Study at
the behavioral and clinical levels of analysis. Setting Academic research. Participants …