CRISPR/Cas-based genome editing in Aspergillus niger
X Zheng, P Zheng, J Sun - Sheng wu Gong Cheng xue bao …, 2021 - europepmc.org
X Zheng, P Zheng, J Sun
Sheng wu Gong Cheng xue bao= Chinese Journal of Biotechnology, 2021•europepmc.orgAspergillus niger is a vital industrial workhouse widely used for the production of organic
acids and industrial enzymes. This fungus is a crucial cell factory due to its innate tolerance
to a diverse range of abiotic conditions, high production titres, robust growth during industrial
scale fermentation, and status as a generally recognized as safe (GRAS) organism. Rapid
development of synthetic biology and systems biology not only offer powerful approaches to
unveil the molecular mechanisms of A. niger productivity, but also provide more new …
acids and industrial enzymes. This fungus is a crucial cell factory due to its innate tolerance
to a diverse range of abiotic conditions, high production titres, robust growth during industrial
scale fermentation, and status as a generally recognized as safe (GRAS) organism. Rapid
development of synthetic biology and systems biology not only offer powerful approaches to
unveil the molecular mechanisms of A. niger productivity, but also provide more new …
Aspergillus niger is a vital industrial workhouse widely used for the production of organic acids and industrial enzymes. This fungus is a crucial cell factory due to its innate tolerance to a diverse range of abiotic conditions, high production titres, robust growth during industrial scale fermentation, and status as a generally recognized as safe (GRAS) organism. Rapid development of synthetic biology and systems biology not only offer powerful approaches to unveil the molecular mechanisms of A. niger productivity, but also provide more new strategies to construct and optimize the A. niger cell factory. As a new generation of genome editing technology, the Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/CRISPR associated (Cas) system brings a revolutionary breakthrough in targeted genome modification for A. niger. In this review, we focus on current advances to the CRISPR/Cas genome editing toolbox, its application on gene modification and gene expression regulation in this fungal. Moreover, the future directions of CRISPR/Cas genome editing in A. niger are highlighted.
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