Recent advances in our ability to design DNA binding factors with specificity for desired
sequences have resulted in a revolution in genetic engineering, enabling directed changes
to the genome to be made relatively easily. Traditional techniques for generating genetic
mutations in most organisms have relied on selection from large pools of randomly induced
mutations for those of particular interest, or time-consuming gene targeting by homologous
recombination. Drosophila melanogaster has always been at the forefront of genetic …