Complement receptor of immunoglobulin superfamily (CRIg) is expressed on liver
macrophages and directly binds complement component C3b or Gram-positive bacteria to
mediate phagocytosis. CRIg plays important roles in several immune-mediated diseases,
but it is not clear how its pathogen recognition and phagocytic functions maintain
homeostasis and prevent disease. We previously associated cytolysin-positive
Enterococcus faecalis with severity of alcohol-related liver disease. Here, we demonstrate …