CTL-mediated selective pressure influences dynamic evolution and pathogenic functions of HIV-1 Nef
T Ueno, C Motozono, S Dohki, P Mwimanzi… - The Journal of …, 2008 - journals.aai.org
HIV-1 Nef plays multiple roles in modulating immune responses, even though it is a
dominant CTL target itself. How Nef accomplishes the balance between such conflicting
selective pressures remains elusive. By genetic and functional studies, we found that Arg 75
Thr and Tyr 85 Phe mutations, located in a well-conserved proline-rich region in Nef, were
differently associated with escape from CTL responses specific for two overlapping HLA-B35-
restricted epitopes. CTLs specific for an epitope, that selected Tyr 85 Phe, were elicited …
dominant CTL target itself. How Nef accomplishes the balance between such conflicting
selective pressures remains elusive. By genetic and functional studies, we found that Arg 75
Thr and Tyr 85 Phe mutations, located in a well-conserved proline-rich region in Nef, were
differently associated with escape from CTL responses specific for two overlapping HLA-B35-
restricted epitopes. CTLs specific for an epitope, that selected Tyr 85 Phe, were elicited …
[PDF][PDF] CTL-Mediated Selective Pressure Influences
M Takiguchi, SR Mwimanzi, OT Fackler, S Oka - J Immunol, 2008 - academia.edu
HIV-1 Nef plays multiple roles in modulating immune responses, even though it is a
dominant CTL target itself. How Nef accomplishes the balance between such conflicting
selective pressures remains elusive. By genetic and functional studies, we found that
Arg75Thr and Tyr85Phe mutations, located in a well-conserved proline-rich region in Nef,
were differently associated with escape from CTL responses specific for two overlapping
HLA-B35-restricted epitopes. CTLs specific for an epitope, that selected Tyr85Phe, were …
dominant CTL target itself. How Nef accomplishes the balance between such conflicting
selective pressures remains elusive. By genetic and functional studies, we found that
Arg75Thr and Tyr85Phe mutations, located in a well-conserved proline-rich region in Nef,
were differently associated with escape from CTL responses specific for two overlapping
HLA-B35-restricted epitopes. CTLs specific for an epitope, that selected Tyr85Phe, were …
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