Ca2+ handling at the mitochondria-ER contact sites in neurodegeneration
Mitochondria-endoplasmic reticulum (ER) contact sites (MERCS) are morpho-functional
units, formed at the loci of close apposition of the ER-forming endomembrane and outer
mitochondrial membrane (OMM). These sites contribute to fundamental cellular processes
including lipid biosynthesis, autophagy, apoptosis, ER-stress and calcium (Ca 2+)
signalling. At MERCS, Ca 2+ ions are transferred from the ER directly to mitochondria
through a core protein complex composed of inositol-1, 4, 5 trisphosphate receptor (InsP 3 …
units, formed at the loci of close apposition of the ER-forming endomembrane and outer
mitochondrial membrane (OMM). These sites contribute to fundamental cellular processes
including lipid biosynthesis, autophagy, apoptosis, ER-stress and calcium (Ca 2+)
signalling. At MERCS, Ca 2+ ions are transferred from the ER directly to mitochondria
through a core protein complex composed of inositol-1, 4, 5 trisphosphate receptor (InsP 3 …
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