Cadmium-induced inflammatory responses in cells relevant for lung toxicity: Expression and release of cytokines in fibroblasts, epithelial cells and macrophages
Inhalation is an important route of cadmium (Cd) exposure, and the lung is considered to be
one of the main target organs of Cd toxicity. Pulmonary inflammation seems to be involved in
development of many lung diseases. In the present study we show that Cd2+ at fairly low
concentrations affects gene expression of several different cytokines/chemokines in human
M1 fibroblasts. The chemokines CXCL2, CXCL3, IL-8/CXCL8 and CCL26, the pro-
inflammatory cytokine IL-6 and the receptor IL-1RL1 were expressed at high levels after …
one of the main target organs of Cd toxicity. Pulmonary inflammation seems to be involved in
development of many lung diseases. In the present study we show that Cd2+ at fairly low
concentrations affects gene expression of several different cytokines/chemokines in human
M1 fibroblasts. The chemokines CXCL2, CXCL3, IL-8/CXCL8 and CCL26, the pro-
inflammatory cytokine IL-6 and the receptor IL-1RL1 were expressed at high levels after …
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