Calcitonin gene‐related peptide is released from capsaicin‐sensitive nerve fibres and induces vasodilatation of human cerebral arteries concomitant with activation of …
I Jansen‐Olesen, A Mortensen, L Edvinsson - Cephalalgia, 1996 - Wiley Online Library
The vasomotor effects of calcilonin gene‐related peptide (CGRP) analogues have been
studied in circular segments of fresh human cereoral arteries obtained at neurosurgical
operations using a sensitive in vitro system. Human a‐CGRP, human b‐CGRP, rat a‐CGRP
and rat b‐CGRP induced strong and potent relaxation of precontracted circular vessel
segments. The Imax (maximum relaxant effect) to human calcitonin was low and the pD2
(concentration for half maximum effect) 7.7 was much lower than that of CGRP. The CGRP …
studied in circular segments of fresh human cereoral arteries obtained at neurosurgical
operations using a sensitive in vitro system. Human a‐CGRP, human b‐CGRP, rat a‐CGRP
and rat b‐CGRP induced strong and potent relaxation of precontracted circular vessel
segments. The Imax (maximum relaxant effect) to human calcitonin was low and the pD2
(concentration for half maximum effect) 7.7 was much lower than that of CGRP. The CGRP …
Calcitonin Gene-Related Peptide is Released from Capsaicin-Sensitive Nerve Fibres and Induces Vasodilatation of Human Cerebral Arteries Concomitant with …
I Jansen, A Mortensen, L Edvinsson - 1996 - arch.neicon.ru
The vasomotor effects of calcilonin gene-related peptide (CGRP) analogues have been
studied in circular segments of fresh human cereoral arteries obtained at neurosurgical
operations using a sensitive in vitro system. Human a-CGRP, human b-CGRP, rat a-CGRP
and rat b-CGRP induced strong and potent relaxation of precontracted circular vessel
segments. The I< sub> max(maximum relaxant effect) to human calcitonin was low and the
pD< sub> 2(concentration for half maximum effect) 7.7 was much lower than that of CGRP …
studied in circular segments of fresh human cereoral arteries obtained at neurosurgical
operations using a sensitive in vitro system. Human a-CGRP, human b-CGRP, rat a-CGRP
and rat b-CGRP induced strong and potent relaxation of precontracted circular vessel
segments. The I< sub> max(maximum relaxant effect) to human calcitonin was low and the
pD< sub> 2(concentration for half maximum effect) 7.7 was much lower than that of CGRP …
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