Candidate mechanisms for chemotherapy-induced cognitive changes
TA Ahles, AJ Saykin - Nature Reviews Cancer, 2007 - nature.com
TA Ahles, AJ Saykin
Nature Reviews Cancer, 2007•nature.comThe mechanism (s) for chemotherapy-induced cognitive changes are largely unknown;
however, several candidate mechanisms have been identified. We suggest that shared
genetic risk factors for the development of cancer and cognitive problems, including low-
efficiency efflux pumps, deficits in DNA-repair mechanisms and/or a deregulated immune
response, coupled with the effect of chemotherapy on these systems, might contribute to
cognitive decline in patients after chemotherapy. Furthermore, the genetically modulated …
however, several candidate mechanisms have been identified. We suggest that shared
genetic risk factors for the development of cancer and cognitive problems, including low-
efficiency efflux pumps, deficits in DNA-repair mechanisms and/or a deregulated immune
response, coupled with the effect of chemotherapy on these systems, might contribute to
cognitive decline in patients after chemotherapy. Furthermore, the genetically modulated …
Abstract
The mechanism(s) for chemotherapy-induced cognitive changes are largely unknown; however, several candidate mechanisms have been identified. We suggest that shared genetic risk factors for the development of cancer and cognitive problems, including low-efficiency efflux pumps, deficits in DNA-repair mechanisms and/or a deregulated immune response, coupled with the effect of chemotherapy on these systems, might contribute to cognitive decline in patients after chemotherapy. Furthermore, the genetically modulated reduction of capacity for neural repair and neurotransmitter activity, as well as reduced antioxidant capacity associated with treatment-induced reduction in oestrogen and testosterone levels, might interact with these mechanisms and/or have independent effects on cognitive function.
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