The feasibility of the application of the catalytic wet air oxidation (CWAO) in two produced water containing refractory organic pollutants [total organic carbon (TOC) content 1,249 and 1,442 mg L⁻¹] were studied. The produced waters were oxidized in a batch reactor using a (4 wt%) Cu/Mn–Ce–O catalyst, prepared by the co-precipitation of manganese and ceria nitrates, followed by wet impregnation of copper acetate. The efficiency of the CWAO of oilfield produced water was determined by TOC removal of the tested wastewater, the Pseudomonas putida growth inhibition test was also accomplished. Approximately 80 % in TOC reduction was achieved during wet oxidation over the catalyst at 433 K and an oxygen partial pressure of 1.0 MPa. No leaching of Cu or Mn was detected.