Aggressive intervention to lower low-density lipoprotein cholesterol (LDL-C) with statin
therapy significantly reduces cardiovascular risk [1]. Target levels of LDL-C levels between
50 to 70 mg/dl and even more aggressive treatment of hypercholesterolemia in high-risk
patients following the dictum of “the lower the better” has been promoted to attempt to
improve cardiovascular and overall mortality [2]. While beneficial effects of lowering LDL-C
have been substantiated in multiple clinical trials, there remains uncertainty regarding …