Celastrus-derived celastrol suppresses autoimmune arthritis by modulating antigen-induced cellular and humoral effector responses
SH Venkatesha, H Yu, R Rajaiah, L Tong… - Journal of Biological …, 2011 - ASBMB
Rheumatoid arthritis (RA) is an autoimmune disease characterized by synovial inflammation
and articular damage. Proinflammatory cytokines, antibodies, and matrix-degrading
enzymes orchestrate the pathogenic events in autoimmune arthritis. Accordingly, these
mediators of inflammation are the targets of several anti-arthritic drugs. However, the
prolonged use of such drugs is associated with severe adverse reactions. This limitation has
necessitated the search for less toxic natural plant products that possess anti-arthritic …
and articular damage. Proinflammatory cytokines, antibodies, and matrix-degrading
enzymes orchestrate the pathogenic events in autoimmune arthritis. Accordingly, these
mediators of inflammation are the targets of several anti-arthritic drugs. However, the
prolonged use of such drugs is associated with severe adverse reactions. This limitation has
necessitated the search for less toxic natural plant products that possess anti-arthritic …
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