BCAT1 promotes tumor cell migration and invasion in hepatocellular carcinoma

M Xu, Q Liu, Y Jia, K Tu, Y Yao, Q Liu… - Oncology …, 2016 - spandidos-publications.com
cells, and silencing of BCAT1 expression reduced the invasion and migration of HCC … of
BCAT1 in HCC cells, the effects of c-Myc- and BCAT1-knockdown on MHCC-97H cells were …

BCAT1 promotes cell proliferation through amino acid catabolism in gliomas carrying wild-type IDH1

M Tönjes, S Barbus, YJ Park, W Wang, M Schlotter… - Nature medicine, 2013 - nature.com
… In our study, suppression of BCAA catabolism by knockdown of BCAT1 resulted in
reduced cell proliferation in vitro and in vivo. The mechanisms through which these metabolic …

Branched-chain amino acid transaminase 1 (BCAT1) promotes the growth of breast cancer cells through improving mTOR-mediated mitochondrial biogenesis and …

L Zhang, J Han - Biochemical and biophysical research communications, 2017 - Elsevier
BCAT1 gene and found that BCAT1 promoted growth and colony formation of breast cancer
cells. … Our results showed that BCAT1 knockdown significantly reduced the growth rate and …

[HTML][HTML] BCAT1 promotes proliferation of endometrial cancer cells through reprogrammed BCAA metabolism

P Wang, S Wu, X Zeng, Y Zhang, Y Zhou… - International journal of …, 2018 - ncbi.nlm.nih.gov
… of BCAT1 loss on tumor cell proliferation, we performed BCAT1BCAT1 knockdown could
efficiently decrease the BCAT1 … leucine were significantly reduced by BCAT1 knockdown. …

BCAT 1, a key prognostic predictor of hepatocellular carcinoma, promotes cell proliferation and induces chemoresistance to cisplatin

YH Zheng, WJ Hu, BC Chen, THM Grahn… - Liver …, 2016 - Wiley Online Library
BCAT1 promotes HCC cell growth both in vitro and in vivo. The enhancement by BCAT1 of
… The overexpression of BCAT1 reduced the percentage of cells in S phase from 19.53 to 8.75…

BCAT1 controls metabolic reprogramming in activated human macrophages and is associated with inflammatory diseases

AE Papathanassiu, JH Ko, M Imprialou… - Nature …, 2017 - nature.com
… (ERG240, a leucine analogue), we show that inhibition of BCAT1 leads to the reduction of …
of BCAA catabolism in these cells. To examine the role of BCAT1 in macrophage metabolism …

[HTML][HTML] BCAT1 knockdown-mediated suppression of melanoma cell proliferation and migration is associated with reduced oxidative phosphorylation

B Zhang, F Xu, K Wang, M Liu, J Li, Q Zhao… - American Journal of …, 2021 - ncbi.nlm.nih.gov
BCAT1-knockdown B16 cells displayed significantly reduced migration ability than the
control cells … Our data showed that BCAT1 knockdown significantly reduced the amount of the …

[HTML][HTML] BCAT1 expression associates with ovarian cancer progression: possible implications in altered disease metabolism

ZQ Wang, A Faddaoui, M Bachvarova, M Plante… - Oncotarget, 2015 - ncbi.nlm.nih.gov
… , BCAT1 depletion induced S cell cycle arrest which could explain the drastic reduction in
the proliferation rates of these EOC cells … mechanisms of BCAT1 action in EOC cells, we …

Enhanced BCAT1 activity and BCAA metabolism promotes RhoC activity in cancer progression

L Qian, N Li, XC Lu, M Xu, Y Liu, K Li, Y Zhang… - Nature …, 2023 - nature.com
… that suppression of BCAT1 in glioma cell lines carrying wild-… leads to reduced proliferation
4 and that BCAT1 protein and … of cell lines, we found that all cell lines with the BCAT1 E61A …

BCAT1 overexpression regulates proliferation and c‑Myc/GLUT1 signaling in head and neck squamous cell carcinoma

H Wang, F Wang, W Ouyang, X Jiang… - Oncology …, 2021 - spandidos-publications.com
… The involvement of BCAT1 in tumor development has been … BCAT1 promotes the proliferation
of cancer cells by … (C) Annexin V/PI staining showing that BCAT1 overexpression reduces