Cellular and molecular landscape of mammalian sinoatrial node revealed by single-cell RNA sequencing
D Liang, J Xue, L Geng, L Zhou, B Lv, Q Zeng… - Nature …, 2021 - nature.com
Bioelectrical impulses intrinsically generated within the sinoatrial node (SAN) trigger the
contraction of the heart in mammals. Though discovered over a century ago, the molecular
and cellular features of the SAN that underpin its critical function in the heart are uncharted
territory. Here, we identify four distinct transcriptional clusters by single-cell RNA sequencing
in the mouse SAN. Functional analysis of differentially expressed genes identifies a core cell
cluster enriched in the electrogenic genes. The similar cellular features are also observed in …
contraction of the heart in mammals. Though discovered over a century ago, the molecular
and cellular features of the SAN that underpin its critical function in the heart are uncharted
territory. Here, we identify four distinct transcriptional clusters by single-cell RNA sequencing
in the mouse SAN. Functional analysis of differentially expressed genes identifies a core cell
cluster enriched in the electrogenic genes. The similar cellular features are also observed in …