ChIP-seq and In Vivo Transcriptome Analyses of the Aspergillus fumigatus SREBP SrbA Reveals a New Regulator of the Fungal Hypoxia Response and Virulence

D Chung, BM Barker, CC Carey, B Merriman… - PLoS …, 2014 - journals.plos.org
… Importantly, the majority of SrbA direct target genes identified in our ChIP-seq analysis
fall into this group of genes with reduced mRNA levels strongly suggesting that SrbA directly …

Regulation of Sterol Biosynthesis in the Human Fungal Pathogen Aspergillus fumigatus: Opportunities for Therapeutic Development

S Dhingra, RA Cramer - Frontiers in microbiology, 2017 - frontiersin.org
… Affinity binding analysis reveals azoles directly bind with … SREBPs to the SRE element in
the promoter region of SrbA … can directly inhibit activation of the SrbA pathway in vivo in A. …

[引用][C] … of SrbB, a New Sterol Regulatory Element Binding Protein Involved in Regulation of the Hypoxia Response and Virulence in Aspergillus fumigatus

D Chung, BM Barker, CC Carey, B Merriman… - 한국미생물학회학술 …, 2015 - dbpia.co.kr
vivo transcriptome analyses using Nanostring nCounter technology. Results from ChIP-seq
and RNA-seq revealed … new insights into complicated roles of SREBPs in adaptation of host …

AtrR is an essential determinant of azole resistance in Aspergillus fumigatus

S Paul, M Stamnes, GH Thomas, H Liu, D Hagiwara… - MBio, 2019 - Am Soc Microbiol
vivo using chromatin immunoprecipitation coupled with high-throughput DNA sequencing
(… transcriptionally responsive to SrbA (18, 22). Our ChIP-seq analysis detected nearly 900 …

SREBP Coordinates Iron and Ergosterol Homeostasis to Mediate Triazole Drug and Hypoxia Responses in the Human Fungal Pathogen Aspergillus fumigatus

M Blatzer, BM Barker, SD Willger, N Beckmann… - PLoS …, 2011 - journals.plos.org
… and reveal dramatic changes in the fungal transcriptome due … attenuated virulence in vivo,
it seems clear that SrbA's role in … as enriched in preliminary ChIP-SEQ analysis (Barker et al. …

[图书][B] … Regulatory Element Binding Protein (SREBP) dependent regulation of gaseous signaling and cell biology during fungal biofilm development in Aspergillus …

S Rajasenan - 2021 - search.proquest.com
… with Aspergillus fumigatusSrbA supports the hypothesis that SrbA plays an important role
in the regulation of biofilm cell biology. Closer analysis of the SrbA activation process reveals

SREBP-Dependent Triazole Susceptibility in Aspergillus fumigatus Is Mediated through Direct Transcriptional Regulation of erg11A (cyp51A)

SJ Blosser, RA Cramer - Antimicrobial agents and chemotherapy, 2012 - Am Soc Microbiol
… is a human fungal pathogen that must adapt to a variety of in vivo … As the analysis of the
ΔsrbA phenotype reveals that several … preliminary SrbA ChIP-Seq data for use in our studies. …

Sterol biosynthesis and azole tolerance is governed by the opposing actions of SrbA and the CCAAT binding complex

F Gsaller, P Hortschansky, T Furukawa, PD Carr… - PLoS …, 2016 - journals.plos.org
… regulatory element binding protein (SREBP) SrbA, and the CCAAT b… (B) & (C) To further
analyse the in vivo binding site for the … analysis of a recent genome-wide ChIP-Seq evaluation of …

RbdB, a Rhomboid Protease Critical for SREBP Activation and Virulence in Aspergillus fumigatus

S Dhingra, CH Kowalski, A Thammahong, SR Beattie… - Msphere, 2016 - Am Soc Microbiol
fumigatus SREBP SrbA is critical for adaptation and growth … pombe revealed that the
SREBP pathway functions as an … the SrbA1-425ΔrbdB strain in vivo may answer this question. …

Regulation of high-affinity iron acquisition, including acquisition mediated by the iron permease FtrA, is coordinated by AtrR, SrbA, and SreA in Aspergillus fumigatus

A Yap, R Volz, S Paul, WS Moye-Rowley, H Haas - MBio, 2023 - Am Soc Microbiol
… (ChIP-seq) analyses previously indicated binding of SrbA … iron sufficiency and the SREBP
SrbA for activation during iron … srbA, or containing deletions of either AtrR or SrbA revealed that …