Childhood trauma and the limbic network: a multimodal MRI study in patients with bipolar disorder and controls
J Souza-Queiroz, J Boisgontier, B Etain… - Journal of Affective …, 2016 - Elsevier
Journal of Affective Disorders, 2016•Elsevier
Background Childhood trauma (CT) is a major risk factor for psychiatric conditions. It is
hypothesized that CT effects are mediated by the limbic system. Few multimodal
neuroimaging studies allow an integrated perspective of this impact. Our goal was thus to
study the effects of CT on the limbic network. Methods We acquired multimodal MRI (T1,
diffusion weighted, and resting state fMRI) data from 79 subjects (47 healthy controls and 32
patients with bipolar disorder, BD). We performed correlational analyses between Childhood …
hypothesized that CT effects are mediated by the limbic system. Few multimodal
neuroimaging studies allow an integrated perspective of this impact. Our goal was thus to
study the effects of CT on the limbic network. Methods We acquired multimodal MRI (T1,
diffusion weighted, and resting state fMRI) data from 79 subjects (47 healthy controls and 32
patients with bipolar disorder, BD). We performed correlational analyses between Childhood …
Background
Childhood trauma (CT) is a major risk factor for psychiatric conditions. It is hypothesized that CT effects are mediated by the limbic system. Few multimodal neuroimaging studies allow an integrated perspective of this impact. Our goal was thus to study the effects of CT on the limbic network.
Methods
We acquired multimodal MRI (T1, diffusion weighted, and resting state fMRI) data from 79 subjects (47 healthy controls and 32 patients with bipolar disorder, BD). We performed correlational analyses between Childhood Trauma Questionnaire (sub)scores (physical and emotional abuse/neglect and sexual abuse) and anatomo-functional measurements of the limbic network (hippocampal and amygdala volumes, prefronto-limbic functional connectivity, uncinate fractional anisotropy).
Results
We found CTQ total scores to be negatively correlated with amygdala volume, prefronto-limbic functional connectivity (FC) and uncinate fractional anisotropy in our sample. Considering subscores, neglects (physical and emotional) were the only to affect neural parameters. The patients with BD drove most of the results.
Limitations
Small sample size and low level of trauma in controls.
Conclusions
Our multimodal approach enabled an integrated view of the long-term effects of CT on the limbic system.
Elsevier
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