Chloride secretion and function of serous and mucous cells of human airway glands
WE Finkbeiner, BQ Shen… - American Journal of …, 1994 - journals.physiology.org
WE Finkbeiner, BQ Shen, JH Widdicombe
American Journal of Physiology-Lung Cellular and Molecular …, 1994•journals.physiology.orgCells from the acini of human tracheal glands were grown in culture to produce confluent
cell sheets of mucous or mixed seromucous phenotype. Levels of mediator-induced Cl
secretion in mucous cells were 2-18% those of seromucous cells. Levels of the cystic fibrosis
transmembrane conductance regulator (an apical membrane Cl channel) were also much
less in mucous than in seromucous cells. These results suggest that serous cells are more
important than mucous cells in providing the fluid component of gland secretions.
cell sheets of mucous or mixed seromucous phenotype. Levels of mediator-induced Cl
secretion in mucous cells were 2-18% those of seromucous cells. Levels of the cystic fibrosis
transmembrane conductance regulator (an apical membrane Cl channel) were also much
less in mucous than in seromucous cells. These results suggest that serous cells are more
important than mucous cells in providing the fluid component of gland secretions.
Cells from the acini of human tracheal glands were grown in culture to produce confluent cell sheets of mucous or mixed seromucous phenotype. Levels of mediator-induced Cl secretion in mucous cells were 2-18% those of seromucous cells. Levels of the cystic fibrosis transmembrane conductance regulator (an apical membrane Cl channel) were also much less in mucous than in seromucous cells. These results suggest that serous cells are more important than mucous cells in providing the fluid component of gland secretions.
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