Cholinergic input from the pedunculopontine nucleus to the cerebellum: implications for deep brain stimulation in Parkinson's disease
E Scarnati, F Vitale, A Capozzo… - Neural Regeneration …, 2016 - journals.lww.com
Deep brain stimulation (DBS) is a well established electrophysiological treatment initially
applied to treat medication-refractory motor symptoms in Parkinson's disease (PD), and is
now being explored for several neurological and psychiatric disorders. The specific
physiological mechanisms underlying the effectiveness of DBS are not fully understood,
although some hypothesized general mechanisms may be acceptable (Wichmann and
DeLong, 2016). Early hypotheses suggested that stimulation of the subthalamic nucleus …
applied to treat medication-refractory motor symptoms in Parkinson's disease (PD), and is
now being explored for several neurological and psychiatric disorders. The specific
physiological mechanisms underlying the effectiveness of DBS are not fully understood,
although some hypothesized general mechanisms may be acceptable (Wichmann and
DeLong, 2016). Early hypotheses suggested that stimulation of the subthalamic nucleus …
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