[HTML][HTML] Chromatin: liquid or solid?

A Zidovska - Cell, 2020 - cell.com
… of chromatin fibers in solid-like and liquid-like states. Bottom inset depicts solid-like
chromatin fibers (blue lines) that serve as a scaffold for nucleation of phase-separated liquid

[HTML][HTML] The solid and liquid states of chromatin

JC Hansen, K Maeshima, MJ Hendzel - Epigenetics & Chromatin, 2021 - Springer
… that can result in solid or liquid chromatin condensates depending on … chromatin and specific
chromatin-associated proteins and relate this in vitro behavior to the properties of chromatin

[HTML][HTML] Condensed chromatin behaves like a solid on the mesoscale in vitro and in living cells

H Strickfaden, TO Tolsma, A Sharma, DA Underhill… - Cell, 2020 - cell.com
… interactions between chromatin fibers. Our results reveal that condensed chromatin exists in
a solid-… a scaffold that supports liquid-liquid phase separation of chromatin binding proteins. …

[HTML][HTML] Chromatin liquidliquid phase separation (LLPS) is regulated by ionic conditions and fiber length

Q Chen, L Zhao, A Soman, AY Arkhipova, J Li, H Li… - Cells, 2022 - mdpi.com
… of chromatin in the cell nucleus is crucial for maintaining cellular homeostasis. Chromatin can
exist in solid- or liquid… suggested that chromatin undergoes liquidliquid phase separation (…

Condensed but liquid-like domain organization of active chromatin regions in living human cells

T Nozaki, S Shinkai, S Ide, K Higashi, S Tamura… - Science …, 2023 - science.org
… Our findings resolve the discrepancy of whether chromatin is liquid-like (38) or solid-like (7).
Both reports are consistent with our results. It is very reasonable that the FRAP experiments, …

[HTML][HTML] Liquid-like behavior of chromatin

K Maeshima, S Ide, K Hibino, M Sasai - Current opinion in genetics & …, 2016 - Elsevier
… discussed liquid-like chromatin behaviors as local chromatin structure and dynamics. Next,
we examine higher-order chromatin structures. It has been long known that chromatin forms …

[HTML][HTML] Fluid-like chromatin: Toward understanding the real chromatin organization present in the cell

K Maeshima, S Tamura, JC Hansen, Y Itoh - Current opinion in cell biology, 2020 - Elsevier
… have drastically shifted our view on chromatin from a static regular structure to a more …
chromatin organization inside the cell. Here we critically discuss our current view on chromatin

Liquidliquid phase separation in chromatin

K Rippe - Cold Spring Harbor perspectives in biology, 2022 - cshperspectives.cshlp.org
… At the same time, the folding of chromatin in the nucleus … chromatin organization, chromatin
binding, and LLPS is discussed by comparing and contrasting three prototypical chromatin

In diverse conditions, intrinsic chromatin condensates have liquid-like material properties

BA Gibson, C Blaukopf, T Lou, L Chen… - Proceedings of the …, 2023 - National Acad Sciences
… between liquid-like and solid-like behavior of chromatin … rely on dynamic rearrangements of
chromatin. Whether such … as in a liquid-like state) or require input of energy (as in a solid-like …

[HTML][HTML] Liquid-like chromatin in the cell: What can we learn from imaging and computational modeling?

Y Itoh, EJ Woods, K Minami, K Maeshima… - Current opinion in …, 2021 - Elsevier
… , chromatin is considered ‘liquid-like’ rather than a solid-like … Indeed, such liquid-like chromatin
condensates were … 23] and that chromatin condensates appear to have a solid-like feature …