Chromosomal aberrations (CA) are the microscopically visible part of a wide spectrum of
DNA changes generated by different repair mechanisms of DNA double strand breaks
(DSB). The method of fluorescence in situ hybridisation (FISH) has uncovered unexpected
complexities of CA and this will lead to changes in our thinking about the origin of CA. The
inter-and intrachromosomal distribution of breakpoints is generally not random. CA
breakpoints occur preferentially in active chromatin. Deviations from expected …